On Reserpine, A New Anti-Hypertensive Alkaloid from Rauwolfia Serpentina

A Priliminary Note on the Pharmacological Study on Reserpine a New Alkaloid Isolated from Rauwolfia Serpentina

Rauwolfia serpentina, Benth, commonly known as Insanity herb has been used for a long time in Ayurvedic System of Indian Medicine. It has been highly advocated as a general sedative in sleeplessness, anxiety neurosia and hysteria and in the treatment of epilepsy, maniacal and acute insanity. Siddiqui & Siddiqui (19321935) studied the chemistry of some of the active principles extracted from the...

Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells.

BACKGROUND The antihypertensive reserpine is an indole alkaloid from Rauwolfia serpentina and exerts also profound activity against cancer cells in vitro and in vivo. The present investigation was undertaken to investigate possible modes of action to explain its activity toward drug-resistant tumor cells. MATERIAL AND METHODS Sensitive and drug-resistant tumor cell lines overexpressing P-glyc...

Action of reserpine-free extract of Rauwolfia serpentina on hypophysis-adrenocortical axis in rat.

(Abstract only) These results show that the alkaloid complex used here (Reserpine free alkaloids of Rauwolfia serpentina) modifies the response of the body to general stress. Thymus atrophy, adrenal enlargement and gastrointestinal ulcers have been described as the triad of ‘alarm reaction’ by SELYE who has also shown that adrenal enlargement due to stress occurs only in the presence of adenoph...

The Use of Rauwolfia serpentina in Hypertensive Patients

The root of Sarpgandha is a species of flowering plant in the family Apocynaceae has been traditionally used in Ayurveda for many years to treat a variety of diseases that at first thought appear to bear little similarity to one another. These include insanity, epilepsy, insomnia, hysteria, eclampsia and hypertension. On reflection, however, these various diseases could have a common denominato...

The use of Rauwolfia serpentina in hypertensive patients.